More than one comparator

Sometimes, it may be appropriate to consider more than one comparator.

Example: "Cost-effectiveness of cholesterol-lowering therapies according to selected patient characteristics".

Source: Prosser,L.A.; Stinnett,A.A.; Goldman,P.A.; Williams,L.W.; Hunink,M.G.; Goldman,L.; Weinstein,M.CSO, Ann Intern Med. 2000; 132(10): 769-79.

In this study, the authors stated that they compared three interventions for cholesterol lowering in primary and secondary prevention of CHD:

• no intervention
• step I diet
• statin treatment