APPRAISE (EEs) page 14 of 85

2. Cost-minimisation analysis

This is a study in which the outcomes are shown to be identical and we just need to compare the relevant costs of the interventions.

Example. “Comparable mean reductions in systolic and diastolic blood pressures were achieved. Treated systolic blood pressure ranged from 128+/-6 mmHg to 130+/-8 mmHg. For diastolic blood pressure the range was 86+/-3 to 88+/-2 mmHg. (values are expressed as mean +/- SD). Since the clinical study showed no difference in benefit between the treatment alternatives, the economic analysis was based on difference in costs only.”

Source: Hilleman D E, et al. Cost-minimisation analysis of initial antihypertensive therapy in patients with mild to moderate essential diastolic hypertension” Clinical Therapeutics 1994;16(1):88-102.

The intervention with the lowest average cost provides the "best value for money".

This page updated on 25/11/05